Pharmaceutical Emulsions by Sarker Dipak Kumar;

Author:Sarker, Dipak Kumar;
Language: eng
Format: epub
Publisher: Wiley
Published: 2013-07-25T16:00:00+00:00

The nanoemulsion represents a huge growth area and adaptation of the coarse emulsion. A combination of multiple emulsifiers (Span, Tween, poloxamers, lipids) and an improvment in manufacturing equipment means 40–100 nm emulsion droplet manufacture is now routinely possible. Efficacy in this case is vastly improved, along with surface area and penetration power (Gregoriadis, 1973, 1977; Torchilin, 2001; Sarker, 2012a). Currently approved nanoemulsion therapeutics and products (Almeida and Souto, 2007) in development include:

NanoStat NB001, an antiviral product (NanoBio), currently in phase III clinical trials.

Rective, a nitroglycerine ointment (Prostraken) for anal discomfort (haemorrhoids/piles/tears), FDA approved (2011).

Intralipid, a nutrition (Pharmacia/Kabi) lipid depot, FDA approved in 1972, EU approved in 1962.

Ropion, a flurbiprofen axetil prodrug nanoemulsion (Kaken) and analgesic, FDA approved.

Palux, a lipid nanosphere platform (for the perfumery industry), FDA approved.

Liple with alprostadil, a vasodilator for erectile dysfunction, FDA approved.

Limathason containing dexamethasone palmitate (Mitsubishi Pharma), FDA approved.

Diprivan with propofol, used for anaesthesia (AstraZeneca), FDA approved.

Omnitrope, a human growth hormone suspension for injection (Sandoz), FDA approved.

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