Radiation Dose Reconstruction for Epidemiologic Uses by Committee on an Assessment of CDC Radiation Studies

Author:Committee on an Assessment of CDC Radiation Studies
Language: eng
Format: epub
Tags: Health and Medicine. Environment and Environmental Studies : Environmental Health and Safety. Environment and Environmental Studies : Radiation
Publisher: NATIONAL ACADEMY PRESS
Published: 1995-05-16T00:00:00+00:00

• measure the stability of persistent biologic markers,

• define "calibration curves" for low to moderate and chronic exposures,

• determine the frequency of specific markers in unexposed populations,

• define the sources of inter-individual variability for various markers, and

• develop better definitions of marker responses after partial-body (external) or specific organ (internal emitter) exposure.

26. New assays should be developed to address the problems with individual variability in background, with identification of differences in individual susceptibility to radiation genotoxicity, and with the lack of sensitivity for quantifying low radiation exposures so that acute doses greater than 0.1 Gy (10 rad) can be reconstructed.

27. Biologic markers of effect should be used as epidemiologic end points. However, until clear connections are established between the marker and the disease, their use could be misleading rather than illuminating.

28. As the utility of biologic markers becomes established and accepted, the committee recommends that the CDC develop procedural strategies for conducting field studies for both specimen collection and laboratory analyses in the event of an acute release of activity.

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