Next Generation Kinase Inhibitors by Unknown

Next Generation Kinase Inhibitors by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030482831
Publisher: Springer International Publishing


121.

Goldstein, D. M., Soth, M., Gabriel, T., Dewdney, N., Kuglstatter, A., Arzeno, H., Chen, J., Bingenheimer, W., Dalrymple, S. A., Dunn, J., Farrell, R., Frauchiger, S., La Fargue, J., Ghate, M., Graves, B., Hill, R. J., Li, F., Litman, R., Loe, B., McIntosh, J., McWeeney, D., Papp, E., Park, J., Reese, H. F., Roberts, R. T., Rotstein, D., San Pablo, B., Sarma, K., Stahl, M., Sung, M.-L., Suttman, R. T., Sjogren, E. B., Tan, Y., Trejo, A., Welch, M., Weller, P., Wong, B. R., & Zecic, H. (2011). Discovery of 6-(2,4-Difluorophenoxy)-2- [3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido- [2,3-d]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)- 8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin- 7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. Journal of Medicinal Chemistry, 54, 2255–2265.PubMed



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