Neoplastic Mimics in Genitourinary Pathology by unknow

Author:unknow
Language: eng
Format: epub
ISBN: 9781617051838
Publisher: Springer
Published: 2013-09-15T05:00:00+00:00

FIGURE 4.117 Androgen deprivation therapy effect on benign prostatic tissue: Simple glands with atrophy and prominent basal cells.

FIGURE 4.118 Androgen deprivation therapy effect on benign prostatic tissue: Vacuolated secretory cells with cleared cytoplasm and a conspicuous basal cell rim.

CRYOSURGERY EFFECT

Cryotherapy to treat prostate cancer involves freezing the prostate gland, creating an intraprostatic ice ball by use of cryoprobes placed under ultrasound guidance. Histologic changes in benign prostatic tissue depend on the time of tissue sampling after treatment. Reparative alterations with stromal fibrosis, hyalinization, and inflammation predominate after 10 weeks (776). At 5 to 48 weeks after cryotherapy the most common microscopic findings in prostate needle biopsies are stromal fibrosis and hyalinization, basal cell hyperplasia, coagulative necrosis, and inflammation (635,777). This tissue damage can persist beyond 1 year (777). Reactive epithelial atypia and basal cell hyperplasia could prompt concern for neoplasia, particularly if this treatment context is not considered. Immunostains for basal cells and AMACR can be useful tools in confirming a benign diagnosis in such cases.

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