Mass Spectrometry Data Analysis in Proteomics by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9781493997442
Publisher: Springer New York

10.Are intense fragment ions observed from cleavage on the N-terminal side of P and the C-terminal side of D? Low-energy CID fragmentation induced by a mobile proton [27] depends on the charge state of the peptide ion and on how the charges are sequestered by basic residues. Numerous studies have described the facile backbone cleavage N-terminal to proline (see for example [28]) because the tertiary amine is more basic than the other backbone atoms. In cases where charges are sequestered (e.g., when the number of protons is lower than the number of arginine residues) there is an enhanced cleavage at aspartic acid residues [27].

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