Big Data Analytics in Genomics by Ka-Chun Wong

Author:Ka-Chun Wong
Language: eng
Format: epub, pdf
Publisher: Springer International Publishing, Cham

2.1.3 Integration of Data Sources in Whole-Sequence Annotation Transfer

Another way to improve whole-sequence methods is to integrate additional data sources. The GOtcha method in [236], for instance, organizes the annotations of sequences similar to a query into a set of GO-like directed acyclic graphs. A P-score is calculated based on the frequency of occurrence of respective annotations and BLAST E-values of the corresponding matches. The P-score estimates the confidence attached to the annotation of the query sequence with that term, and a threshold value for the P-score allows extracting a final set of annotations. Evaluation of this approach on the Drosophila melanogaster genome showed that the results were more sensitive and specific than those obtained with the baseline approach.

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