How Not to Study a Disease by Karl Herrup

How Not to Study a Disease by Karl Herrup

Author:Karl Herrup
Language: eng
Format: epub
Tags: Alzheimer's disease; dementia; plaques and tangles; PhRMA (Pharmaceutical Research and Manufacturing Association); NIH (National Institutes of Health); NIA (National Institute on Aging); Alzheimer's vaccine; brain; correlation versus causality; evidence-based medicine; animal models of human disease; history of science
Publisher: MIT Press


Determining how much drug development costs contribute to the total is surprisingly hard. The companies tend not to break down their research expenditures in a very granular way, and that makes it difficult to know how the funds listed as “research and development” are spent:

… “quite a lot” of things can be incorporated into R&D expenditures, such as legal expenses for acquiring and defending intellectual property rights, commercial activities, and fees paid to doctors for participation in clinical trials.4



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