Thoracic Pathology: A Volume in the High Yield Pathology Series (Expert Consult - Online and Print) by Husain Aliya

Author:Husain, Aliya [Husain, Aliya]
Language: eng
Format: epub
ISBN: 9781455737888
Publisher: Elsevier Health Sciences
Published: 2012-02-14T00:00:00+00:00

Pathology

Histology

• Lesions are characterized by angiocentric and angiodestructive polymorphous lymphoid infiltrate; lymphocytic vasculitis and infiltration into the vascular wall is present in most cases

• Larger lesions commonly demonstrate central necrosis

• Small lymphocytes predominate and are admixed with plasma cells, immunoblasts, and histiocytes

• Neutrophils and eosinophils are usually inconspicuous

• Within the inflammatory infiltrate is a variable number of large EBV+ B cells

• The EBV-positive cells may resemble immunoblasts or, less commonly, resemble Hodgkin cells and may be multinucleated

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