Emergency Neurology by Sara LaHue MD;Morris Levin MD;

Author:Sara LaHue MD;Morris Levin MD;
Language: eng
Format: epub
Publisher: OUP Premium
Published: 2021-06-15T00:00:00+00:00

Table 19.2 Comparison of oral anticoagulants for stroke prophylaxis in patients with nonvalvular atrial fibrillation

Anticoagulant Warfarin Apixaban (Eliquis) Dabigatran (Pradaxa) Rivaroxaban (Xarelto)

Mechanism Vitamin K antagonist Selective direct factor Xa inhibitor Competitive direct thrombin inhibitor Selective direct factor Xa inhibitor

Routine level monitoring Variable: semi-weekly to monthly None None None

Dosing frequency Per pharmacist Twice daily Twice daily Nightly

Dosing considerations No renal dose adjustment. Dose adjustment based on age, weight, and/or renal function Dose adjustment based on renal function Dose adjustment based on renal function

Antidote 10 mg vitamin K IV and four-factor prothrombin complex concentrate (if not available, use fresh frozen plasma). Andexanet alfa (AndexXa) Idarucizumab (Praxbind) Andexanet alfa (AndexXa)

Comparison with warfarin for stroke prevention ARISTOTLE: Superior to warfarin RELY: Superior to warfarin in intention-to-treat analysis ROCKET-AF: Non-inferior to warfarin.

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